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American scientists grow transplant bladders in the lab E-mail
Monday, 10 April 2006
American scientists grow transplant bladders in the lab
American scientists have successfully transplanted bladders grown in the laboratory from patients' own cells into people suffering with bladder disease and the team is now working to grow 20 other internal organs including hearts using the same technique.

The research team, from North Carolina's Wake Forest University, have so far carried out seven transplants, and in some patients the organ is still working well years later.


This incredible achievement, which has been detailed online by The Lancet medical journal, is being described as a "milestone".

The scientific research team had discovered seven young patients who had a congenital condition called myelomeningocele, which causes a weak bladder and they took a bladder biopsy from each patient and isolated muscle cells and special bladder cells called urothelial cells, which they then grew in the lab.

The cells were then put into a specially designed bladder-shaped scaffold and left to grow for seven to eight weeks and the researchers surgically attached the bladder they had grown to the patient's own bladder and followed progress for up to five years.

They discovered that bladder function got better without any of the side effects associated with the technique when using bowel tissue.

Lead researcher Dr Anthony Atala said: "This is one small step in our ability to go forward in replacing damaged tissues and organs."

But Dr Richard Horton, editor of The Lancet, the journal, which published information on the new research, said the science of growing organs was still at an early stage.
 

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Last Updated ( Wednesday, 12 April 2006 )
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