The court in Paris heard how the seven accused had concealed the dangers of the treatment from the parents of the children and had violated rules of safety.
The health officials deny the charges but each could face up to 10 years imprisonment if found guilty.
It is considered probable that other children who received the treatment will also succumb to CJD in the future at some point.
The prosecution allege that the accused had knowingly extracted hormones from the pituitary glands of corpses in hospitals specialising in infectious diseases, and that it was possible that such corpses were infected with CJD.
In the early 1980s, many countries, including America and Britain, had banned the extraction of hormones from pituitary glands, however, France carried on with the practice until 1988.
Lawyers representing the accused claim in their defence that their clients acted in good faith, and only had the medical knowledge of the time to make decisions with.
